The psychotherapy conducted under LSD intoxication included 12 homosexual males (6 ephebophilic and 6 androphilic subjects) and 6 transsexual females. The transsexual females were non-neurotic and no traumatism was found in their sociopsychic sphere. Despite their excellent co-operation the therapy revealed an absolute hopelessness of adaptation of their socio-sexual orientation. LSD was rather inclined to promote the disorder. The homosexual males were neurotic and their anamnesis was rich in sociopsychic conflicts and traumatism. In four out of five the therapy caused the frequency of neurotic symptoms to fall, in 75 % of cases there was improvement as regards their social relations. Each second patient showed also different levels of psychosexual adaptation. Jv. Cas. Lék. ces., 113, 1974, No. 48, p. 1491-1493.